منابع مشابه
A SUMO-Phospho tag team for wrestling with potassium channel gating
435 C o m m e n t a r y Voltage-gated potassium (Kv) channels play an essential role in regulating membrane excitability. Among ion channels, Kv channels are exceptional in their genetic diversity and in that their gene products can coassemble with one another and with auxiliary subunits to generate a broad spectrum of channel structures and functions (Vacher et al., 2008). As a consequence, in...
متن کاملSUMO wrestling with Ras
This review discusses our current understanding of the small ubiquitin-like modifier (SUMO) pathway and how it functionally intersects with Ras signaling in cancer. The Ras family of small GTPases are frequently mutated in cancer. The role of the SUMO pathway in cancer and in Ras signaling is currently not well understood. Recent studies have shown that the SUMO pathway can both regulate Ras/MA...
متن کاملSUMO wrestling with Drp1 at mitochondria.
Mitochondria undergo dynamic fission and fusion events, and disruptions in this balance can lead to cellular dysfunction or death. New work by Henley and colleagues identifies a key role for the SUMO protease SENP3 and its target Drp1, a key mediator of mitochondrial fission, in ischaemia. The term mitochondrion is derived from the Greek mitos (thread) and khondrion (small grain), emphasizing t...
متن کاملWinning Isn’t Everything: Corruption in Sumo Wrestling
There is a growing appreciation among economists of the need to better understand the role that corruption plays in real-world economies. Although some have argued that it can be welfare enhancing (Nathaniel Leff, 1964), most commentators believe that a willingness to accept bribes (or similar forms of corruption) in either the public or the private sector reduces economic ef ciency (Andrei Sh...
متن کاملSUMO Modification: Wrestling with Protein Conformation
SUMO modification of human thymine-DNA glycosylase facilitates the processing of base excision repair substrates by an unusual mechanism: while leaving the catalytic center unaffected, it induces product release by eliciting a conformational change in the enzyme.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2005
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2005.05.017